Advanced Biochemistry

Applies the principles of organic chemistry to biochemistry. Explores enzymology through the lenses of mechanistic organic chemistry, bioinorganic chemistry, and catalysis. Covers how proteins orchestrate the reactivity of functional groups, the range of cofactors employed to extend the scope and diversity of biocatalysis, enzymatic systems controlled by their kinetics, and how knowledge of enzyme reaction mechanisms enable modern drug design. Weeks 1-6 Foundations of Mechanistic Enzymology; Weeks 7-12 Biosynthetic Chemistry, Drug action, metabolism and design. Biological electron transfer.