This course covers major diseases (cancer, diabetes, heart disease, infectious diseases), the physical changes that inflict morbidity and mortality, the design constraints for treatment, and emerging technologies that take into account these physical hurdles. Taking the perspective of the design constraints on the system (that is, the mass transport and biophysical limitations of the human body), we will survey recent innovations from the fields of drug delivery, gene therapy, tissue engineering, and nanotechnology.

This course looks at the formation of a techne ("art" or "science") of medicine in fifth-century BCE Greece and debates about the theory and practice of healthcare in Greco-Roman antiquity. We look at early Greek medicine in relationship to established medical traditions in Egypt and Mesopotamia; medical discourses of human nature, gender, race, and the body; debates about the ethics of medical research; the relationship of the body to the mind; and the nature of "Greek" medicine as it travels to Alexandria, Rome and Baghdad. Readings drawn from primary sources as well as contemporary texts in medical humanities and bioethics.

Health economics is a growing field of applied microeconomics and is an important aspect of public policy. This course explores the health care sector and health policy issues from an economic perspective. Microeconomics tools will be used to analyze the functioning of different pieces of the health care system. Topics will range from fundamental subjects, such as the demand for health, to more recent developments, such as mental health, child health and risky health behaviors. This course teaches an economic approach to studying the various policies that affect health and health behaviors.

This required course for GHP students explores how we study the distribution and determinants of disease, introducing methods for measuring health status, disease occurrence, the association between risk factors and health outcomes, probing evidence for causality, and characterizing how ecology shapes human health. Emphasis on: study design and sampling, bias and confounding, the generalizability of research, identifying causality, infectious disease dynamics, global health.

We will explore the molecular events leading to the onset and progression of human cancer. We will review the central genetic and biochemical elements that make up the cell cycle, followed by a survey of the signal transduction pathways and checkpoints that regulate it. We will discuss oncogenes, tumor suppressor and mutator genes that act in these pathways and review the role of viral oncogenes and their action on cells. We will investigate the role of cancer stem cells and the interaction between tumor and the host environment. We will explore specific clinical case studies in light of the molecular events underlying different cancers.

This course will consider the principles, development, outcomes and future directions of therapeutic applications of biotechnology, with particular emphasis on the interplay between basic research and clinical experience. Topics to be discussed include production of hormones and other protein drugs, nucleic acid drugs and vaccines, gene therapy and gene editing, and molecular diagnostics. Reading will largely be from the primary literature.

The objectives of this course are to understand the bio-psycho-social/processes that influence health-related behaviors, health and wellness, and health-care delivery. Topics to be examined include the psycho-physiological, neuro-psychological and socio-cultural bases of health and illness; pain; adaptation to chronic illness; stress; personality and illness; death, dying, and grief; substance use; obesity and nutrition.

This course explores the biochemical foundations of human physiology and how it is disturbed in disease. We discuss the roles of metabolic, the cardiovascular, and immune systems in various diseases, particularly cancer. Specific topics include: the functions of the major organ systems, and how we measure and model their activity; nutrition and the maintenance of metabolic homeostasis; the anti-tumor immune response; the origins, consequences, and major treatment paradigms of cancer; and the process of translating basic science into novel therapies. The class will consist of lectures and student-led discussions of scientific papers.

The Affordable Care Act, enacted in 2010, was the defining (and polarizing) initiative of the Obama era, with provisions to expand health insurance coverage, control health care costs, and improve the health care delivery system. This course will focus on the history of health reform, as well as implementation challenges since the law's enactment. We will examine the federal regulatory process, the many legal challenges to the law, the role that states have played in implementation, and Congressional repeal efforts. We will also investigate the role of federalism in health care policy and the future of health care reform.